Q) What is PRP?
PRP Platelet-rich plasma (PRP) is autologous concentration of platelets contained in small
volume of plasma which accelerates the rejuvenation of skin and hair follicles due to
presence of various growth factors.It has an above baseline platelet concentration (usually
more than 1,000,000 platelets/µL) leading to 300–700% enrichment.
Q) What are the uses of PRP?
PRP therapy has been traditionally used in tissue regeneration to promote healing during
many procedures in maxillofacial surgery, soft tissue injuries, etc.. PRP specifically is now been used by
dermatologists for management of various alopecias and for skin rejuvenation.
Q) How is PRP derived?
PRP is derived from the centrifugation of the patient's own blood and it contains growth
factors working on different target cells that influence wound healing, thereby playing an
important role in tissue repair mechanisms, enhancing soft tissue healing and regeneration at
Q) How does PRP work?
PRP contains more than 20 types of growth factors which regulate cell migration,
proliferation, remodelling of the extracellular matrix (ECM) and promotion of angiogenesis,
creating a beneficial environment for enhanced wound healing. More than 1 million/µL of
platelet concentration (about four to seven times the mean levels) is therapeutically effective
concentration. Concentrations higher or lower than1.5 million platelets/µL inhibit the
angiogenic potential in human endothelial cells.
The platelets actively secrete growth factors within 10 minutes after activation and more than
ninety five percent of the presynthesized growth factors are secreted within one hour.
Therefore, PRP should be used within 10 minutes of activation.
Q) What are the contraindications of PRP?
01. Absolute contraindications:
02. Relative contraindications:
Q) Are there any Complications of PRP?
PRP is a relatively safe procedure. Though minor complications are mentioned as pain in the injected area; headache, heaviness of head, swelling, redness, infection, allergic reaction- urticarial rash, temporary skin discoloration, bruising . PRP is autologous and hence no potential side effects compared to pre-existing therapeutic modalities or high degree of compliance. Also, as the mechanism of action of PRP is different from other treatments, an additive positive effect may be there on using PRP as an adjuvant to minoxidil and finasteride.